Sulfate reducing bacteria induce α-synuclein in intestinal and neuronal cells and tissues and inhibit tyrosine hydroxylase in neuronal cells

IntroductionParkinson’s disease (PD), a synucleopathy characterized by the presence of α-synuclein (α-syn) aggregates in the brain, is thought to originate in the intestine. Desulfovibrio, resident gut sulfate reducing bacteria (SRB), usually found in very low numbers in a healthy gut, are found in...

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Autores principales:	Sudha B. Singh, Arianne J. Capacio, Cody A. Braun, Amanda Carroll-Portillo, Sephira Ryman, Henry C. Lin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-12-01
Colección:	Frontiers in Neuroscience
Materias:	Parkinson’s disease α-synuclein (α-syn) sulfate reducing bacteria Desulfovibrio vulgaris (DSV) tyrosine hydroxylase
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1672793/full
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