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Epigenetic Factors in Pathogenesis of Retinoblastoma: DNA Methylation and Histone Acetylation

(Background) Retinoblastoma is the most common intraocular malignancy in childhood, primarily caused by mutations in the <i>RB1</i> gene. However, increasing evidence highlights the significant role of epigenetic mechanisms, particularly DNA methylation and histone acetylation, in tumor initiation a...

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Principais autores: Georgios Kiosis, Kanellos Skourtsidis, Despoina Ioannou, Vasilis-Spyridon Tseriotis, Konstantinos Stergiou, Fani Akritidou, Theodora Papamitsou, Maria Kourti, Sofia Karachrysafi
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2025-10-01
Series:Current Issues in Molecular Biology
Assuntos:
retinoblastoma
epigenetics
DNA methylation
histone acetylation
Acceso en liña:https://www.mdpi.com/1467-3045/47/10/844
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