Beyond tumors: uninvolved breast tissue of breast cancer patients with adverse prognoses is enriched for pathogenic PIK3CA and TP53 post-zygotic variants

Abstract Background Histologically normal mammary tissue from breast cancer patients can harbor significant genetic alterations that could precede visible tumor development and influence disease progression. Methods Whole-exome sequencing was performed on 408 samples from 77 breast cancer patients w...

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Hauptverfasser:	Maria Andreou, Katarzyna Chojnowska, Natalia Filipowicz, Monika Horbacz, Piotr Madanecki, Katarzyna Duzowska, Urszula Ławrynowicz, Hanna Davies, Bożena Bruhn-Olszewska, Mikołaj Koszyński, Kinga Drężek-Chyła, Maciej Jaśkiewicz, Marcin Jąkalski, Anna Kostecka, Marta Drzewiecka-Kłysz, Magdalena Nowikiewicz, Manuela Las-Jankowska, Dariusz Bała, Jacek Hoffman, Ewa Śrutek, Michał Jankowski, Jerzy Jankau, Diana Hodorowicz-Zaniewska, Joanna Szpor, Łukasz Szylberg, Wojciech Zegarski, Tomasz Nowikiewicz, Patrick G. Buckley, Irene Tiemann-Boege, Jakub Mieczkowski, Magdalena Koczkowska, Jan P. Dumanski, Arkadiusz Piotrowski
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-04-01
Schriftenreihe:	BMC Cancer
Schlagworte:	Breast cancer Recurrence Post-zygotic variants Unfavorable outcome Uninvolved mammary gland
Online-Zugang:	https://doi.org/10.1186/s12885-026-16086-z
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