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Engineered Multivalent Nanobodies Efficiently Neutralize SARS-CoV-2 Omicron Subvariants BA.1, BA.4/5, XBB.1 and BQ.1.1

Most available neutralizing antibodies are ineffective against highly mutated SARS-CoV-2 Omicron subvariants. Therefore, it is crucial to develop potent and broad-spectrum alternatives to effectively manage Omicron subvariants. Here, we constructed a high-diversity nanobody phage display library and...

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Hoofdauteurs: Jiali Wang, Bingjie Shi, Hanyi Chen, Mengyuan Yu, Peipei Wang, Zhaohui Qian, Keping Hu, Jianxun Wang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2024-04-01
Reeks:Vaccines
Onderwerpen:
SARS-CoV-2
Omicron subvariants
phage display library
receptor-binding domain (RBD)
multivalent nanobodies
neutralizing activity
Online toegang:https://www.mdpi.com/2076-393X/12/4/417
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