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Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism

The small-molecule drug voriconazole (VRC) shows a complex and not yet fully understood metabolism. Consequently, its in vivo pharmacokinetics are challenging to predict, leading to therapy failures or adverse events. Thus, a quantitative in vitro characterization of the metabolism and inhibition pr...

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Principais autores: Josefine Schulz, Antonia Thomas, Ayatallah Saleh, Gerd Mikus, Charlotte Kloft, Robin Michelet
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-02-01
coleção:Pharmaceutics
Assuntos:
voriconazole
drug metabolism
pharmacokinetics
CYP P450 enzymes
CYP inhibition
intersystem extrapolation factors
Acesso em linha:https://www.mdpi.com/1999-4923/14/3/477
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