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Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.

Furkejuvvon:
Váldodahkkit: Joe Nassour, Sébastien Martien, Nathalie Martin, Emeric Deruy, Elisa Tomellini, Nicolas Malaquin, Fatima Bouali, Laure Sabatier, Nicolas Wernert, Sébastien Pinte, Eric Gilson, Albin Pourtier, Olivier Pluquet, Corinne Abbadie
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2016-01-01
Ráidu:Nature Communications
Liŋkkat:https://doi.org/10.1038/ncomms10399
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