Pituitary Adenylate Cyclase-Activating Polypeptide—A Neuropeptide as Novel Treatment Option for Subacute Ileitis in Mice Harboring a Human Gut Microbiota

The neuropeptide Pituitary adenylate cyclase-activating polypeptide (PACAP) is well-known for its important functions in immunity and inflammation. Data regarding anti-inflammatory properties of PACAP in the intestinal tract are limited, however. In our present preclinical intervention study we addr...

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Principais autores:	Stefan Bereswill, Ulrike Escher, Anne Grunau, Anja A. Kühl, Ildiko R. Dunay, Andrea Tamas, Dora Reglodi, Markus M. Heimesaat
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-03-01
coleção:	Frontiers in Immunology
Assuntos:	pituitary adenylate cyclase-activating polypeptide (PACAP) subacute ileitis Th1-type immunopathology human fecal microbiota transplantation gut-brain axis preclinical intervention study
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00554/full
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