Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms. Here the authors show that Plk4 undergoes phase separation into an assembling body through autophos...
שמור ב:
| Principais autores: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Portfolio
2019-10-01
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| סדרה: | Nature Communications |
| גישה מקוונת: | https://doi.org/10.1038/s41467-019-12619-2 |
| תגים: |
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