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Optimization of Proanthocyanidin Extraction from Grape Seeds Using Response Surface Methodology and Subsequent Evaluation of Its Antioxidant and Immunomodulatory Capacities

This study employed UPLC-MS/MS to determine the contents of major polyphenolic compounds and proanthocyanidins (PCs) in Kyoho grape seeds, optimized the extraction method and conditions for PCs using response surface methodology (RSM), and further evaluated the scavenging activities of PCs against 2...

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Principais autores: Jiawei Zhang, Yali Yao, Yingjun Ru, Defu Tang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-04-01
coleção:Foods
Assuntos:
UPLC-MS/MS
proanthocyanidins
response surface methodology (RSM)
oxidative stress
immunosuppression
Acesso em linha:https://www.mdpi.com/2304-8158/15/7/1214
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