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Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide–hydantoin hybrids

A novel series of hydantoins incorporating phthalimides has been synthesised by condensation of activated phthalimides with 1-aminohydantoin and investigated for their inhibitory activity against a panel of human (h) carbonic anhydrase (CA, EC 4.2.1.1): the cytosolic isoforms hCA I, hCA II, and hCA...

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Autors principals: Morteza Abdoli, Alessandro Bonardi, Paola Gratteri, Claudiu T. Supuran, Raivis Žalubovskis
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2024-12-01
Col·lecció:Journal of Enzyme Inhibition and Medicinal Chemistry
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Accés en línia:https://www.tandfonline.com/doi/10.1080/14756366.2024.2335927
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