GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Direct targeting of mutant KRas is challenging and alternative approaches are needed. Here they show glycogen synthase kinase 3 (GSK3) to be required for the growth and survival of human mutant KRas-dependent tumors but dispensable for mutant KRas-independent tumors and show GSK3 inhibition to inhib...

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Detalhes bibliográficos

Principais autores:	Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Daniel Delitto, José Trevino, Rays H. Y. Jiang, Muhammad Ayaz, Harshani R. Lawrence, Perry Kennedy, Saïd M. Sebti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2018-12-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-018-07644-6
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