Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

Despite the central role of amyloid β (Aβ) peptide in the etiopathogenesis of Alzheimer’s disease (AD), its physiological function in healthy brain is still debated. It is well established that elevated levels of Aβ induce synaptic depression and dismantling, connected with neurotoxicity and neurona...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Vesna Lazarevic, Sandra Fieńko, Maria Andres-Alonso, Daniela Anni, Daniela Ivanova, Carolina Montenegro-Venegas, Eckart D. Gundelfinger, Michael A. Cousin, Anna Fejtova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-07-01
coleção:	Frontiers in Molecular Neuroscience
Assuntos:	amyloid beta acetylcholine receptors synaptic vesicle recycling neurotransmitter release CDK5 calcineurin
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00221/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!