Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction

Abstract Background SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry....

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Ngā kaituhi matua:	Shijulal Nelson-Sathi, P. K. Umasankar, E. Sreekumar, R. Radhakrishnan Nair, Iype Joseph, Sai Ravi Chandra Nori, Jamiema Sara Philip, Roshny Prasad, K. V. Navyasree, Shikha Ramesh, Heera Pillai, Sanu Ghosh, T. R. Santosh Kumar, M. Radhakrishna Pillai
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2022-01-01
Rangatū:	BMC Molecular and Cell Biology
Ngā marau:	SARS-CoV-2 Spike protein Receptor binding domain Mutations ACE2 Binding interface
Urunga tuihono:	https://doi.org/10.1186/s12860-021-00403-4
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