Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia

Introduction:Polygonatum cyrtonema Hua (PC) is an essential herbal medicine in China, known for improving muscle quality and enhancing physical function; its active ingredients are polysaccharides (PCPs). A previous study revealed the anti-atrophy effects of PCPs in cachectic mice. However, whether...

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Hauptverfasser: Rongrong Zhou, Tingting Liu, You Qin, Jing Xie, Shuihan Zhang, Yi Xie, Jia Lao, Wei He, Hongliang Zeng, Xueyang Tang, Xuefei Tian, Yuhui Qin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-03-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
Polygonatum cyrtonema Hua polysaccharides
chemotherapy-induced cachexia
muscle atrophy
gut microbiota
fecal metabolites
short-chain fatty acids
Online Zugang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1503785/full
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