Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling

Rho-GTPases are central regulators within a complex signaling network that controls cytoskeletal organization and cell movement. The network includes multiple GTPases, such as the most studied Rac1, Cdc42, and RhoA, along with their numerous effectors that provide mutual regulation through feedback...

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Bibliographic Details

Main Authors:	Siarhei Hladyshau, Jorik P. Stoop, Kosei Kamada, Shuyi Nie, Denis Tsygankov
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2023-06-01
Series:	Cells
Subjects:	multiscale modeling morphodynamics Rho family GTPases FRET-based biosensors cytoskeletal regulation
Online Access:	https://www.mdpi.com/2073-4409/12/12/1638
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