Quercitrin neutralizes sPLA2IIa activity, reduces the inflammatory IL-6 level in PC3 cell lines, and exhibits anti-tumor activity in the EAC-bearing mice model

Human phospholipase A2 group IIa (sPLA2IIa) is an inflammatory enzyme that plays a significant role in tumorigenesis. Inhibiting the sPLA2IIa enzyme with an effective molecule can reduce the inflammatory response and halt cancer progression. The present study evaluates quercitrin, a biflavonoid, for...

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Autors principals:	P. Sophiya, Deepadarshan Urs, Jafar K. Lone, A. S. Giresha, H. Krishna Ram, J. G. Manjunatha, Hamed A. El-Serehy, M. Narayanappa, J. Shankar, Ragini Bhardwaj, Sameer Ahmad Guru, K. K. Dharmappa
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-10-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	quercitrin sPLA 2 IIa inhibition IL-6 ADME-toxicity inflammation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2022.996285/full
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