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Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance

Abstract Background The burden of Clostridioides difficile as a nosocomial- and community-acquired pathogen has been increasing over the recent decades, including reports of severe outbreaks. Molecular and virulence genotyping are central for the epidemiological surveillance of this pathogen, but ne...

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Principais autores: Semeh Bejaoui, Sofie Holtsmark Nielsen, Astrid Rasmussen, John Eugenio Coia, Dorte Terp Andersen, Tobias Bruun Pedersen, Martin Vad Møller, Marc Trunjer Kusk Nielsen, Dorte Frees, Søren Persson
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-01-01
Serier:BMC Genomics
Fag:
Clostridioides difficile
Whole genome sequencing (WGS)
Illumina
Oxford Nanopore
Epidemiological surveillance
Genotyping
Online adgang:https://doi.org/10.1186/s12864-025-11267-9
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