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Beyond ketosis: the search for the mechanism underlying SGLT2-inhibitor benefit continues

Despite the impressive clinical benefits and widespread adoption of sodium glucose cotransporter 2 inhibitors (SGLT2i) to treat all classes of heart failure, their cardiovascular mechanisms of action are poorly understood. Proposed mechanisms range broadly and include enhanced ketogenesis, where the...

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Autori principali: Justin H. Berger, Brian N. Finck
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2024-12-01
Serie:The Journal of Clinical Investigation
Accesso online:https://doi.org/10.1172/JCI187097
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