Inhibition of mTOR prevents ROS production initiated by ethidium bromide-induced mitochondrial DNA depletion.

The regulation of mitochondrial mass and DNA content involves a complex interaction between mitochondrial DNA replication machinery, functional components of the electron transport chain, selective clearance of mitochondria, and nuclear gene expression. In order to gain insight into cellular respons...

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Detalhes bibliográficos

Principais autores:	Timothy eNacarelli, Ashley eAzar, Christian eSell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2014-07-01
coleção:	Frontiers in Endocrinology
Assuntos:	Aging Mitochondria senescence mTOR rapamycin ROS
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00122/full
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