Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies

Oxaliplatin-based chemotherapy is a standard treatment approach for colorectal cancer (CRC). However, oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe dose-limiting clinical problem that might lead to treatment interruption. This neuropathy may be reversible after treatment discontinu...

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Principais autores:	Fang Cheng, Ruoqi Zhang, Chen Sun, Qian Ran, Cuihan Zhang, Changhong Shen, Ziqing Yao, Miao Wang, Lin Song, Cheng Peng
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2023-08-01
叢編:	Frontiers in Pharmacology
主題:	oxaliplatin peripheral neurotoxicity colorectal cancer adverse reaction mechanism pharmacokinetics
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1231401/full
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