Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

Summary: Loss of insulin-secreting β-cells in diabetes may be either due to apoptosis or dedifferentiation of β-cell mass. The ubiquitin-proteasome system comprising E3 ligase and deubiquitinases (DUBs) controls several aspects of β-cell functions. In this study, screening for key DUBs identified US...

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Hlavní autoři:	Meenal Francis, Smitha Bhaskar, Saarwani Komanduri, Preethi Sheshadri, Jyothi Prasanna, Anujith Kumar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-05-01
Edice:	iScience
Témata:	Molecular interaction Diabetology Specialized functions of cells
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2589004223008489
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