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Rice Nudix Hydrolase OsNUDX2 Sanitizes Oxidized Nucleotides

Nudix hydrolase (NUDX) hydrolyzes 8-oxo-(d)GTP to reduce the levels of oxidized nucleotides in the cells. 8-oxo-(d)GTP produced by reactive oxygen species (ROS) is incorporated into DNA/RNA and mispaired with adenine, causing replicational and transcriptional errors. Here, we identified a rice <i>Os...

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Autori principali: Yuki Kondo, Kazuhide Rikiishi, Manabu Sugimoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-09-01
Serie:Antioxidants
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Accesso online:https://www.mdpi.com/2076-3921/11/9/1805
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