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Virtual birefringence imaging and histological staining of amyloid deposits in label-free tissue using autofluorescence microscopy and deep learning

Abstract Systemic amyloidosis involves the deposition of misfolded proteins in organs/tissues, leading to progressive organ dysfunction and failure. Congo red is the gold-standard chemical stain for visualizing amyloid deposits in tissue, showing birefringence under polarization microscopy. However,...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Xilin Yang, Bijie Bai, Yijie Zhang, Musa Aydin, Yuzhu Li, Sahan Yoruc Selcuk, Paloma Casteleiro Costa, Zhen Guo, Gregory A. Fishbein, Karine Atlan, William Dean Wallace, Nir Pillar, Aydogan Ozcan
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2024-09-01
Sraith:Nature Communications
Rochtain ar líne:https://doi.org/10.1038/s41467-024-52263-z
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