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Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection.

Trypanosoma cruzi infection is characterized by chronic parasitism of non-lymphoid tissues and is rarely eliminated despite potent adaptive immune responses. This failure to cure has frequently been attributed to a loss or impairment of anti-T. cruzi T cell responses over time, analogous to the T ce...

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Detalhes bibliográficos
Principais autores: Angela D Pack, Matthew H Collins, Charles S Rosenberg, Rick L Tarleton
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2018-11-01
coleção:PLoS Pathogens
Acesso em linha:https://doi.org/10.1371/journal.ppat.1007410
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