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Dabrafenib and trametinib administration in patients with BRAF V600E/R or non-V600 BRAF mutated advanced solid tumours (BELIEVE, NCCH1901): a multicentre, open-label, and single-arm phase II trialResearch in context

Summary: Background: BRAF V600 mutations are common in melanoma, thyroid, and non-small-cell lung cancers. Despite dabrafenib and trametinib being standard treatments for certain cancers, their efficacy across various solid tumours remains unelucidated. The BELIEVE trial assessed the efficacy of da...

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Furkejuvvon:
Váldodahkkit: Tatsunori Shimoi, Kuniko Sunami, Makoto Tahara, Satoshi Nishiwaki, Shota Tanaka, Eishi Baba, Masashi Kanai, Ichiro Kinoshita, Hidekazu Shirota, Hideyuki Hayashi, Naohiro Nishida, Toshio Kubo, Nobuaki Mamesaya, Yayoi Ando, Natsuko Okita, Taro Shibata, Kenichi Nakamura, Noboru Yamamoto
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2024-03-01
Ráidu:EClinicalMedicine
Fáttát:
Bayesian statistics
Platform clinical trials
BRAF inhibitors
MEK inhibitors
Rare cancers
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2589537024000269
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