A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer

SOX2 amplification and overexpression represents a hallmark of squamous cancers with distinct distribution of chromatin accessible regions depending on cancer type. Here, the authors identify a single enhancer e1 that predominantly drives SOX2 expression in squamous cancer.

Detalhes bibliográficos

Principais autores:	Yanli Liu, Zhong Wu, Jin Zhou, Dinesh K. A. Ramadurai, Katelyn L. Mortenson, Estrella Aguilera-Jimenez, Yifei Yan, Xiaojun Yang, Alison M. Taylor, Katherine E. Varley, Jason Gertz, Peter S. Choi, Andrew D. Cherniack, Xingdong Chen, Adam J. Bass, Swneke D. Bailey, Xiaoyang Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2021-12-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-021-27055-4
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