Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling

PTP1B and TC-PTP are highly related protein-tyrosine phosphatases (PTPs) that regulate the JAK/STAT signaling cascade essential for cytokine-receptor activation in immune cells. Here, we describe a novel immunotherapy approach whereby monocyte-derived dendritic cell (moDC) function is enhanced by mo...

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Detalhes bibliográficos

Principais autores:	Claudia Penafuerte, Matthew Feldhammer, John R. Mills, Valerie Vinette, Kelly A. Pike, Anita Hall, Eva Migon, Gerard Karsenty, Jerry Pelletier, George Zogopoulos, Michel L. Tremblay
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2017-06-01
coleção:	OncoImmunology
Assuntos:	dendritic cells (dcs) immunotherapy protein-tyrosine phosphatases ptp1b tc-ptp
Acesso em linha:	http://dx.doi.org/10.1080/2162402X.2017.1321185
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