Mechanism of Atractylenolide Ⅲ alleviating pyrotinib-induced diarrhea by regulating AMPK/CFTR pathway through metabolite of gut microbiota

Atractylenolide III, a sesquiterpene extracted from the rhizome of Atractylodes macrocephala (Asteraceae), exhibits pharmacological effects, including improvement of gastrointestinal function, regulation of immune function, anti-inflammatory and antibacterial properties. Pyrotinib, a representative...

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Detalhes bibliográficos

Principais autores:	Fengxian Jiang, Pancen Ran, Liyin Pan, Jingjiang Lai, Junlei Zhang, Jing Zhao, Wei Xu, Jingliang Wang, Yang Shu, Yahui Wang, Rui Zhao, Weihao Wang, Jian Wei, Guobin Fu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-03-01
coleção:	Journal of Traditional and Complementary Medicine
Assuntos:	Atractylenolide III Pyrotinib-induced diarrhea Chloride secretion Gut microbiota Metabolites
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2225411024001378
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