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trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT2 receptor family

A strategy to replace the ethylamine side chain of 2,5-dimethoxy-4-iodoamphetamine (DOI, 1a), and 2,5-dimethoxy-4-bromoamphetamine (DOB, 1b) with a cyclopropylamine moiety was successful in leading to compounds with high affinity at the 5-HT2 family of receptors; and the more potent stereoisomer of...

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Principais autores: Adam Pigott, Stewart Frescas, John D. McCorvy, Xi-Ping Huang, Bryan L. Roth, David E. Nichols
Format: Artigo
Sprog:Inglês
Udgivet: Beilstein-Institut 2012-10-01
Serier:Beilstein Journal of Organic Chemistry
Fag:
cyclopropanation
diazomethane
hallucinogen
5-HT2A agonist
receptor probe
trans-2-phenylcyclopropylamines
Online adgang:https://doi.org/10.3762/bjoc.8.194
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