Melatonin promotes cytotoxicity while reducing cell motility and antioxidant defenses in ovarian cancer cell lines

Ovarian cancer (OC), a highly recurrent and fatal tumor, poses diagnostic challenges due to generic symptoms and chemoresistance. Melatonin (Mel) is an indoleamine acting against tumor progression and exhibiting pro-oxidative actions in tumor cells. This in vitro study explores the impact of Mel on...

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Hauptverfasser: Henrique Spaulonci Silveira, Roberta Carvalho Cesário, Vinicius Augusto Simão, Fernando Guimarães, Fábio Rodrigues Ferreira Seiva, Debora Aparecida P.C. Zuccari, Glaura Scantamburlo Alves Fernandes, Milena Cremer de Souza, Russel J. Reiter, Luiz Gustavo de Almeida Chuffa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2025-12-01
Schriftenreihe:Toxicology Reports
Schlagworte:
Ovarian cancer
Melatonin
Oxidative stress
Antioxidant defense
Catalase
Cell invasion and migration
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2214750025002689
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