Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly

Abstract The type IV pilus family uses PilT/VirB11-like ATPases to rapidly assemble and disassemble pilin subunits. Among these, the tight adherence (Tad) pilus performs both functions using a single bifunctional ATPase, CpaF. Here, we determine three conformationally distinct structures of CpaF hex...

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Autors principals:	Ian Y. Yen, Gregory B. Whitfield, John L. Rubinstein, Lori L. Burrows, Yves V. Brun, P. Lynne Howell
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-04-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-59009-5
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