Understanding the role of the hematopoietic niche in Huntington's disease's phenotypic expression: in vivo evidence using a parabiosis model

In a previous study, we have shown that parabiotic coupling of a knock-in mouse model (zQ175) of Huntington's disease (HD) to wild-type (WT) littermates resulted in a worsening of the normal phenotype as seen by detection of mutant huntingtin protein (mHTT) aggregates within peripheral organs and th...

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Detalhes bibliográficos

Principais autores:	Marie Rieux, Melanie Alpaugh, Shireen Salem, Alberto Siddu, Martine Saint-Pierre, Hélèna L. Denis, Heike Rohweder, Frank Herrmann, Chantal Bazenet, Steve Lacroix, Francesca Cicchetti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-05-01
coleção:	Neurobiology of Disease
Assuntos:	Huntington's disease Parabiosis Mutant huntingtin protein zQ175 Irradiation Hematopoietic stem cells
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996123001055
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