Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome

Shiga toxin (Stx)-producing <i>Escherichia coli</i> is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae. We previously showed that C3a has a critical rol...

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Egile Nagusiak:	Simona Buelli, Monica Locatelli, Claudia Elisa Carminati, Daniela Corna, Domenico Cerullo, Barbara Imberti, Luca Perico, Maurizio Brigotti, Mauro Abbate, Carlamaria Zoja, Ariela Benigni, Giuseppe Remuzzi, Marina Morigi
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2022-05-01
Saila:	Cells
Gaiak:	podocytes proximal tubular epithelial cells complement C3a/C3aR signaling mitochondrial damage
Sarrera elektronikoa:	https://www.mdpi.com/2073-4409/11/11/1755
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