Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance

ABSTRACT The Antibody Mediated Prevention (AMP) trials showed that passively infused VRC01, a broadly neutralizing antibody (bNAb) targeting the CD4 binding site (CD4bs) on the HIV-1 envelope protein (Env), protected against neutralization-sensitive viruses. We identified six individuals from the VR...

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Hlavní autoři:	Paula Cohen, Bronwen E. Lambson, Nonhlanhla N. Mkhize, Chivonne Moodley, Anna E. J. Yssel, Thandeka Moyo-Gwete, Talita York, Asanda Gwashu-Nyangiwe, Nonkululeko Ndabambi, Ruwayhida Thebus, Michal Juraska, Allan C. deCamp, Brian D. Williamson, Craig A. Magaret, Peter B. Gilbert, Dylan Westfall, Wenjie Deng, James I. Mullins, Lynn Morris, Carolyn Williamson, Penny L. Moore
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2025-02-01
Edice:	Journal of Virology
Témata:	HIV-1 broadly neutralizing antibodies VRC01 escape acquisition bottleneck
On-line přístup:	https://journals.asm.org/doi/10.1128/jvi.01730-24
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