Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity.

BACKGROUND:Activation of Ras oncogene in human tumors is associated with radiation-associated metastatic potential. Although ionizing radiation is one important method of cancer treatments, it has been shown to enhance matrix metalloproteinases (MMPs) activity and facilitates a more aggressive cance...

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Bibliografiske detaljer

Principais autores:	Chih-Chia Yu, Chien-An Chen, Shu-Ling Fu, Hon-Yi Lin, Moon-Sing Lee, Wen-Yen Chiou, Yu-Chieh Su, Shih-Kai Hung
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2018-01-01
Serier:	PLoS ONE
Online adgang:	http://europepmc.org/articles/PMC6201887?pdf=render
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