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Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients

Abstract Hydroxyurea (HU) is found to be beneficial in sickle cell anaemia (SCA) patients, due to its ability to increase foetal haemoglobin (HbF), however, patients show a variable response. Differences in HbF levels are attributed to many factors; but, the role of miRNA in HbF regulation is sparse...

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Principais autores: Neha Kargutkar, Madhavi Sawant-Mulay, Priya Hariharan, S. Chandrakala, Anita Nadkarni
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2023-01-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-022-25444-3
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