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Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.

The mechanistic and therapeutic differences in the cellular response to DNA-damaging compounds are not completely understood, despite intense study. To expand our knowledge of DNA damage, we assayed the effects of 12 closely related DNA-damaging agents on the complete pool of approximately 4,700 bar...

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Autors principals: William Lee, Robert P St Onge, Michael Proctor, Patrick Flaherty, Michael I Jordan, Adam P Arkin, Ronald W Davis, Corey Nislow, Guri Giaever
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2005-08-01
Col·lecció:PLoS Genetics
Accés en línia:http://europepmc.org/articles/PMC1189734?pdf=render
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