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GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABAA receptors

Summary: Striatal dopamine axons co-release dopamine and gamma-aminobutyric acid (GABA), using GABA provided by uptake via GABA transporter-1 (GAT1). Functions of GABA co-release are poorly understood. We asked whether co-released GABA autoinhibits dopamine release via axonal GABA type A receptors (...

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Hlavní autoři: Jyoti C. Patel, Ang D. Sherpa, Riccardo Melani, Paul Witkovsky, Madeline R. Wiseman, Brian O’Neill, Chiye Aoki, Nicolas X. Tritsch, Margaret E. Rice
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2024-03-01
Edice:Cell Reports
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On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124724001621
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