Biosynthesis of novel cannabigerolic acid derivatives by engineering the substrate specificity of aromatic prenyltransferase

IntroductionCannabinoids possess significant therapeutic potential, but their natural chemical diversity derived from plant biosynthesis is limited. Efficient biotransformation processes are required to expand the range of accessible cannabinoids. This study aimed to enhance the selective biosynthes...

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Principais autores:	Hoe-Suk Lee, Jisu Park, Taejung Kim, Huitae Min, Seongsu Na, Soon Young Park, Young-Tae Park, Young Joo Yeon, Jungyeob Ham
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Bioengineering and Biotechnology
Assuntos:	cannabinoid cannabigerolic acid derivative aromatic prenyltransferase NphB computational enzyme design engineered E. coli whole cell biocatalytic system
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1563708/full
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