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Garin3 regulates sperm-oocyte fusion and male fertility

Abstract The interaction between sperm and the zona pellucida (ZP), which involves the binding of sperm surface ligands to complementary carbohydrates on the ZP, is the initial direct contact between gametes and is crucial for subsequent gamete fusion and successful mammalian fertilization. In this...

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Main Authors: Zhixian Chen, Siyuan Xie, Guowei Zou, Hongying Zhu, Lei Wang, Xiaoxi Sun, Jian Mu, Qing Sang
Format: Artigo
Language:Inglês
Published: Springer 2026-05-01
Series:Cellular and Molecular Life Sciences
Subjects:
Garin3 deficiency
Fertilization failure
Male infertility
Sperm-zona pellucida binding
Online Access:https://doi.org/10.1007/s00018-026-06225-x
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