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Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis

We performed next-generation sequencing in patients with familial steroid-sensitive nephrotic syndrome (SSNS) and identified a homozygous segregating variant (p.H310Y) in the gene encoding clavesin-1 (CLVS1) in a consanguineous family with 3 affected individuals. Knockdown of the clavesin gene in ze...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Brandon M. Lane, Megan Chryst-Stangl, Guanghong Wu, Mohamed Shalaby, Sherif El Desoky, Claire C. Middleton, Kinsie Huggins, Amika Sood, Alejandro Ochoa, Andrew F. Malone, Ricardo Vancini, Sara E. Miller, Gentzon Hall, So Young Kim, David N. Howell, Jameela A. Kari, Rasheed Gbadegesin
Hōputu: Artigo
Reo:Inglês
I whakaputaina: American Society for Clinical investigation 2022-01-01
Rangatū:JCI Insight
Ngā marau:
Nephrology
Urunga tuihono:https://doi.org/10.1172/jci.insight.152102
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