Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABAA Receptor Activity

GABAA receptors (GABAARs) play a crucial inhibitory role in the CNS. Benzodiazepines (BDZs) are positive modulators of specific subtypes of GABAARs, but the underlying mechanism remains obscure. Early studies demonstrated the major impact of BDZs on binding and more recent investigations indicated g...

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Ngā kaituhi matua:	Magdalena Jatczak-Śliwa, Katarzyna Terejko, Marek Brodzki, Michał A. Michałowski, Marta M. Czyzewska, Joanna M. Nowicka, Anna Andrzejczak, Rakenduvadhana Srinivasan, Jerzy W. Mozrzymas
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2018-08-01
Rangatū:	Frontiers in Cellular Neuroscience
Ngā marau:	GABAA receptor γ-aminobutyric acid benzodiazepines spontaneous activity preactivation gating
Urunga tuihono:	https://www.frontiersin.org/article/10.3389/fncel.2018.00237/full
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