SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

The SPOP gene, which encodes an E3 ubiquitin ligase adaptor, is frequently mutated in a number of cancer types. However, the mechanisms by which SPOP functions as a tumor suppressor remain poorly understood. Here, we show that SPOP promotes senescence, an important tumor suppression mechanism, by ta...

Полное описание

Библиографические подробности

Главные авторы:	Hengrui Zhu, Shancheng Ren, Benjamin G. Bitler, Katherine M. Aird, Zhigang Tu, Emmanuel Skordalakes, Yasheng Zhu, Jun Yan, Yinghao Sun, Rugang Zhang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2015-11-01
Серии:	Cell Reports
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2211124715011377
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!