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EpiMII: Structure-Aware Graph Neural Networks for MHC-II Epitope Generation

Major histocompatibility complex class II (MHC-II) neoantigens play a critical role in immunotherapy, either as direct effectors or through their influence on CD8+ T cells. However, only a small fraction of tumor DNA mutations qualify as functional neoantigens, and current prediction tools suffer fr...

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Hlavní autoři: Jiayi Yuan, Xiaowei Xu, Ze-Yu Sun, Shan Zhu, Chunyu Wei, Tianjian Liang, Jingxuan Ge, Xiang-Qun Xie, Yan Chen, Zhiwei Feng, Tingjun Hou, Ying Xue
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science (AAAS) 2026-01-01
Edice:Research
On-line přístup:https://spj.science.org/doi/10.34133/research.1311
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