Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques

Adeno-associated virus (AAV) vectors are increasingly used as an effective and safe approach to deliver genetic material to the central nervous system (CNS). The AAV9-derived variants, AAV-PHP. B and AAV-PHP.eB, reportedly broadly transduce cells throughout the CNS compared to the original serotype...

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Principais autores:	Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2021-11-01
Series:	Frontiers in Bioengineering and Biotechnology
Assuntos:	adeno-associated virus intrathecal injection CNS non-human primate animal model
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fbioe.2021.762209/full
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