Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage

Abstract Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment with artemisinin (AT) downregulates the protein levels of MMP3, MMP13, and ADAMTS5, which are cartilage d...

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Bibliografske podrobnosti

Principais autores:	Jin Li, Mengqing Jiang, Zhentang Yu, Chenwei Xiong, Jieen Pan, Zhenhai Cai, Nanwei Xu, Xindie Zhou, Yong Huang, Zhicheng Yang
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2022-07-01
Serija:	Cellular & Molecular Biology Letters
Teme:	Artemisinin PI3K/AKT signaling pathway Autophagy TNFSF11 Mitochondria Osteoarthritis
Online dostop:	https://doi.org/10.1186/s11658-022-00365-1
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