Sex-specific transcriptional regulation in lung macrophages during sub-acute Mycobacterium tuberculosis infection

ABSTRACT Biological sex significantly influences susceptibility to tuberculosis (TB), with males typically experiencing a greater disease burden than females. However, the mechanisms underlying sex-specific immune regulation during TB pathogenesis remain incompletely understood. In this study, we ex...

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Detalhes bibliográficos

Principais autores:	Dhanya Dhanyalayam, Hariprasad Thangavel, Kezia Lizardo, Jigar V. Desai, Jyothi F. Nagajyothi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-12-01
coleção:	Microbiology Spectrum
Assuntos:	Mycobacterium tuberculosis sex-specific immune regulation macrophages transcriptomic profiling host-pathogen interactions AKT-IFN-γ signaling
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.01790-25
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