Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis

The necrosis of pancreatic acinar cells is a key molecular event in the progression of acute pancreatitis (AP), with disturbances in mitochondrial energy metabolism considered to be a direct causative factor of acinar cell necrosis. Histidine triad nucleotide-binding protein 2 (HINT2) has been impli...

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Autors principals:	Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-02-01
Col·lecció:	Pharmacological Research
Matèries:	Histidine triad nucleotide-binding protein 2 Mitochondrial oxidative phosphorylation Emodin pancreatic acinar necrosis acute pancreatitis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1043661825000453
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