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Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis

Abstract Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence, progression, invasion, and metastasis of solid tumors. In this process, the tumor microenvironment (TME) fractures cellular and matrix architecture normality through biochemi...

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Principais autores: Hanying Zhou, Meng Wang, Yixi Zhang, Qingqing Su, Zhengxin Xie, Xiangyan Chen, Ran Yan, Ping Li, Tingting Li, Xiang Qin, Hong Yang, Chunhui Wu, Fengming You, Shun Li, Yiyao Liu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2022-05-01
Serier:Cancer Communications
Fag:
tumor microenvironment
mechanical model
mechanosensing
mechanotransduction
cytoskeleton remodeling
Online adgang:https://doi.org/10.1002/cac2.12294
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