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A novel Chimeric Antigen Receptor (CAR) - strategy to target EGFRVIII-mutated glioblastoma cells via macrophages

Abstract Background Autologous chimeric antigen receptor (CAR) expressing T-Cells (CAR-T) have been efficiently used in hematological malignancies but their efficacy in solid tumors remains limited. CAR therapies via the use of macrophages, offer a promising avenue due to their unique ability to inf...

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Autori principali: Kristi Vera, Gülen Esken, Jin Wook Hwang, Carine Elbaz, Diana Chaker, Noufissa Oudrhiri, Christophe Desterke, Frank Griscelli, Annelise Bennaceur-Griscelli, Ali G Turhan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-05-01
Serie:BMC Cancer
Soggetti:
Macrophages: CAR-Macrophages
EGFRvIII
Glioblastoma
Phagocytosis
Accesso online:https://doi.org/10.1186/s12885-026-16080-5
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